CombinatoRx, Inc. is a biopharmaceutical company focused on developing new medicines built from
synergistic combinations of approved drugs. Many diseases affect the body through multiple
biological pathways. We believe that by targeting multiple pathways, their combination drug
candidates may create synergistic therapeutic effects, which could result in improved
treatments for many diseases. CombinatoRx has discovered and advanced into clinical trials a
portfolio of seven product candidates targeting multiple immuno-inflammatory diseases and
cancer. We are located in Boston, Ma.
The Senior Biostatistician/Analyst will participate in the design of new studies; create
statistical analysis plans, program summary tables and QC table and listing programming using
SAS®. In the newly created Biostatistics department, the Senior Biostatistician/Analyst will
be a key contributor in executing standard reporting methods for clinical trial data and
interfacing with the clinical department.
Perform analysis of clinical trial data for projects. Have strong technical skills with
ability to explain, interpret, and utilize complex statistical procedures.
Write statistical analysis plans and reports.
Provide statistical input to study design, develop the statistical section of protocols,
calculate sample sizes, review case report forms.
Assume responsibility for the analysis and reporting of clinical trial data.
Act as an integral member of project team. Attend project team meetings; work with SAS
programmers, data managers, physicians, and clinical research associates, as appropriate.
Perform/understand SAS programming using techniques as SAS macro language, advanced data
manipulation techniques, and statistical procedures (e.g., PROC GLM, PROC FREQ, PROC REPORT).
Perform quality review of statistical analyses.
Review and provide feedback for Data Integrity Plans.
Be familiar with FDA regulations which affect the statistical reporting of clinical trial
data. This includes good clinical practice.
Program statistical analyses (i.e., tables, listings, figures, and inferential statistical
output) using SAS and provide QC review.
Interface with CRO as applicable.
Education and Experience
M.S., Biostatistics or equivalent with at least 4 years of pharmaceutical, biotechnology, or
equivalent experience, or Ph.D. in Biostatistics or equivalent with at least 2 years of
pharmaceutical, biotechnology, or equivalent experience.
Excellent oral and written communication skills.
Strong organizational skills; ability to handle multiple projects with aggressive
Successfully completed several projects.
Familiarity with coding dictionaries (MedDRA and WHO).
Ability to communicate technical concepts clearly and concisely to non-technical colleagues.
CombinatoRx is an Equal Opportunity Employer.
There is no relocation assistance.
Send resume to firstname.lastname@example.org